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Links to other projects or laboratories

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Researche and Training project linked to CEREBNET:
FP7-ICT-2009-6 Collaborative project REALNET-"Realistic Real time Networks: computation dynamics in the cerebellum". Link here
The brain circuits of the central nervous system are formed by neurons and synapses endowed with complex dynamical properties. However, the traditional architectures of computational systems, like artificial neuronal networks, are based on connectivity rules while making use of very simplified neurons. Moreover while brain circuits operate through discontinuous signal called spikes organized in complex sequences, theoretical analysis usually deals with continuous signals. To understand circuit computations a different approach is needed: to elaborate realistic spiking networks and use them, together with experimental recordings of network activity, to investigate the theoretical basis of central network computation. As a benchmark we will use the cerebellar circuit. The cerebellum is supposed to compare expected and actual activity patterns and to reveal their congruence with respect to stored memories. By these means, the cerebellum takes part to control loops regulating movement and cognition. Experimental evidence has revealed that cerebellar circuits can dynamically regulate their activity on the millisecond time scale and operate complex spatio-temporal transformation of signals through non-linear neuronal responses. Moreover, synaptic connections can be fine-tuned by distributed forms of synaptic plasticity, the correlate of memory in neural circuits. In this project, we will develop specific chips and imaging techniques to perform neurophysiological recordings from multiple neurons in the cerebellar network. Based on the data, we will develop the first realistic real-time model of the cerebellum and connect it to robotic systems to evaluate circuit functioning under closed-loop conditions. The data deriving from recordings, large-scale simulations and robots will be used to explain circuit functioning through the “adaptable filter theory”. REALNET will thus provide a radically new view on computation in central brain circuits laying the basis for new technological applications in sensori-motor control and cognitive systems.

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PhD School in Biomedical Sciences. Link here

The “Dottorato in Scienze Biomediche” (DRSBM) is a PhD program coordinated by Prof. Egidio D’Angelo.

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Brain Connectivity Center (BCC). Link here

Mondino Foundation was established with the idea of combining the researches on the central nervous system function (at cellular-molecular level and at anatomo-functional level) with the clinical observations in a variety of neurological disorders, with the aim of identifying new diagnostic and therapeutic approaches.

The main purpose of BCC is to examine in depth the physiopathology of several disorders through an integrated approach between the Laboratory of Neurophysiology (our Lab), University of Pavia, with a number of laboratories and research centers of Mondino Foundation

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ENC - Network. Link here

The ENC academic home institutes all have a long and established track record in PhD training in the field of Preclinical and Clinical Neurosciences. Together they have established the socalled European Neuroscience Campus Network (ENC Network). The ENC network consortium has previously successfully collaborated to promote young group leaders in the field of Neuroscience, within the Network of European Neuroscience Institutes (ENI-Net). In addition we have used our previous collaborations as the ‘stepping stone’ to outline a common strategy.


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C7 - Cerebellar-Cortical Control:Cells, Circuits, Computation, and Clinic. Link here

The C7 network brings together 9 research groups, 5 industrial partners, and 2 patient organizations that form a European institute that conducts a truly interdisciplinary study of the cerebellum.

With electrophysiology, behavioural and clinical research, computational modelling and neuroimaging we will aim to answer three important questions:

  1. What computation is performed in cerebellar networks?
  2. How do distributed synaptic changes lead to learning?
  3. How do cortico-cerebellar loops generate motor control and cognition?

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Brain Training Program. Link Here

Brain disorders are among the most prevalent and debilitating diseases. Because they are chronic, quality of life and socio-economic prospects are dramatically impaired.

Increased life expectancy further enhances the impact of brain dysfunction on society. In coming decades this burden will grow into one of most pressing and costly problems of the EU.

BrainTrain builds on our knowledge of genome information and exploits innovative technologies to unravel the (dys)function of living neurons, networks and the whole brain.

BrainTrain will deliver 17 skilled Phd students prepared for future challenges in neuroscience.

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