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Publications

Posters & Conferences:

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Sathyaa Subramaniyam

Subramaniyam S., Perin P., Locatelli F., Masetto S., Solinas S., and D' Angelo E.Poster: The mechanisms of late-onset synaptic responses in a realistic model of Unipolar Brush Cells. Number P79, OCNS 2013, Paris, July 13-18, 2013. 

Locatelli F., Subramaniyam S., Prestori F., Solinas S., Mapelli L., Masetto S. and D'Angelo E. Poster: Multiple bursting evoked by mossy fiber bundle stimulation in Unipolar Brush Cell: Experimental evidence and computational modeling. NEUROSCIENCE: New Orleans, October 13-17 2012.

Subramaniyam S., Perin P., Locatelli F., Masetto S., Solinas S., and D' Angelo E.Presentation. Realistic Modeling Of Cerebellar Unipolar Brush Cell Intrinsic Excitability. Code: p153.23 - Abstract Number: 1045 - Poster Board Number: D23 FENS, Barcellona July, 14-18, 2012. 

Subramaniyam S., Perin P., Solinas S. D' Angelo E. Modeling UBC intrinsic excitability. Gordon Conference, New London, US, August 21-26, 2011. 

Subramaniyam S., Solinas S., and D' Angelo E. Modeling UBC intrinsic excitability. OCNS 2011, Stockholm, July 23-28, 2011. 

Subramaniyam S., Perin P., Solinas S. D' Angelo E. Realistic modeling cerebellar UBC intrinsic excitability. Presentation Code: B517 IBRO, Italy, July, 14-18, 2011. 

Subramaniyam S., Medini C., Nair B., Diwakar S. Modeling spatio-temporal processing in cerebellar granular layer and effects of controlled inhibition on plasticity. Neurocomp (Lyon, France), 2010, Oct 6-8, 2010. 

 

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Shyam Kumar

Shyam Kumar S., Erik De Schuder.  A biophysical model of cerebellar molecular layer interneuron.  OCNS 2013, Paris,Paris: July 13-18, 2013. Link here

T.G. Close, I. Raikov, S. Kumar and E. De SchutterExploring the limitations of simulator independence via an implementation of a biophysically detailed cerebellar cortex model in NEURON and NEST. BMC Neuroscience, 14 (Suppl 1): P93 (2013). Link here

T.G. Close, I. Raikov, M. Negrello, S. Kumar and E. De Schutter. Exploring the functional implications of brain architecture and connectivity: a multi-simulator framework for biophysical neuronal models. BMC Neuroscience: 13 (Suppl 1): P150 (2012). Link here

I. Raikov, M. Negrello, T.G. Close, S. Kumar and E. De Schutter. Exploring the functional implications of brain architecture and connectivity: a declarative language framework. BMC Neuroscience: 13 (Suppl 1): P151 (2012). Link here

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Hermina Nedelescu

H. Nedelescu, M. Negrello, H. Contuse, M. Häusser, A. Watt and E. De Schutter. Visualizing the developing Purkinje cell dendritic forest using multicolor Brainbow mice. FENS Abstracts 6: 2995 (2012).  Link here

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Erik De Schutter 

S.K. Sudhakar, M. Negrello and E. De Schutter. A modeling study of how inhibition spreads through molecular layer gap junctions in the cerebellar cortex. FENS Abstracts 6: 3279 (2012). Link here

S. Sudhakar and E. De Schutter. A biophysical model of cerebellar molecular layer interneuron. BMC Neuroscience 14 (Suppl 1): P96 (2013). Link here

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Ramakrishnan.K.B

Ramakrishnan.K.B and Egidio D’Angelo. Theta-sensory input induced Long-term potentiation (LTP) in Purkinje cell layer of rat cerebellum. Poster presented at 8th FENS forum of neuroscience, Barcelona (14-18 July 2012).Link her

Ramakrishnan.K.B; Paola Lombardo and Egidio D’Angelo. Millisecond-precise timing of sensory information coding in Purkinje cells of rat cerebellum. Poster presented at 8thworld congress of IBRO, Florence (14-18 July 2011).Link here 

Ramakrishnan.K.B; Paola Lombardo and Egidio D’Angelo. Timing of the sensory information coding in the cerebellar cortex: anin-vivo electrophysiological study. Poster presented at the CSN School on Neurophysiology Techniques 2011, Padova (14 - 18 March 2011). 

Ramakrishnan.K.B; M.Giugliano and E. De Schutter. Fast inhibition of deep cerebellar nucleus neurons by Purkinje cells during tactile stimulation: An in-vivo electrophysiological study. Poster presented at Belgian society for neuroscience (BSN)conference, Liege (11 - May 2009). 

Ramakrishnan.K.B; K. Tahon; R. Maex and E. De Schutter. Fast inhibition of deep cerebellar nucleus neurons by Purkinje cells during tactile stimulation. Poster presented at 6th FENS forum of European Neuroscience, Geneva (12-16 July 2008). Neeraj Jain, Hui-Xin Qi, 

K.B.RamakrishnanJon H Kaas. Reorganization of the Motor Cortex following early dorsal column lesions. Poster presented at NBRC, Manesar (19-20 July 2005). 

Shsahsnak Tandon, K.B.RamakrishnanLesleeLazar and Neeraj Jain. Effects of injuries to the dorsal spinal cord on the organization of the sensorimotor cortex. Poster presented at Indian Academy of Neuroscience conference, Gwalior (26-28 January 2005). 

K.B. Ramakrishnan, Egidio D’Angelo.Long-term potentiation is induced by sensory stimulation in Purkinje cell in vivo. Manuscript in preparation.

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Charlotte Arlt

Arlt, C., Wilms, C.D., Häusser, M. (2013). Dual recordings from cerebellar interneurons and Purkinje cells in vivo. Abstract 647.21, Society for Neuroscience Meeting, San Diego, CA. 

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Jesus Garrido 

Garrido, J. A.; Ros, E.; D’Angelo, E. Open-Source Brain Kick off meeting. Cerebellar cell and network models (13-15 May 2013). Invited talk: “Distributed synaptic plasticity controls spike-timing at the cerebellar granular layer: predictions from a computational model”. Sardinia (Italy). 

Garrido, J. A.; Ros, E.; D’Angelo, EOCNS 2013 conference (13-18 July 2013). Poster presentation: “Distributed synaptic plasticity controls spike-timing: predictions from a cerebellar computational model”. Paris (France).

Garrido, J. A.; Ros, E.; D’Angelo, EOCNS workshop. Computations in the cerebellar circuit - advances on the modeling front. (17-18 July 2013). Invited talk: “Millisecond-scale regulation of spike timing by distributed synaptic plasticity at the cerebellum input stage”. Paris (France).

Garrido, J. A.; Ros, E.; D’Angelo, EGordon Research Conference on Cerebellum (11-16 August 2013). Poster presentation: “Millisecond-scale regulation of spike timing by distributed synaptic plasticity at the cerebellar granular layer”. New London (United States).

Garrido, J. A.; Ros, E.; D’Angelo, ESociety for Neuroscience Annual Meeting (9-13 November 2013). Poster presentation: “Spike timing regulation on the millisecond scale by distributed synaptic plasticity at the cerebellum granular layer”. San Diego (United States).

Garrido, J.A., Ros, E., D'Angelo, E. Int. Realnet Consortium Meeting and Annual Review (12 March-13 March, 2012). Invited talk: “Real-time simulation of the cerebellar network”. European Commission. Brussels (Belgium).

Garrido, J.A., Ros, E., D'Angelo, E. ENC/Braintrain/CEREBNET consortium annual joint meeting (12 July-13 July). Oral presentation: “The impact of distributed synaptic plasticity on spike timing in the cerebellar input layer: a simulation study.” Barcelona (Spain).

FENS Forum 2012 (14 July-18 July). Poster presentation: Garrido, J.A., Luque, N.R., D'Angelo, E, Ros, E. “Enhancing learning precision at parallel fiber – purkinje cell connections through deep cerebellar nuclei LTD and LTP”. Barcelona (Spain).

Granada Conference on Computational and Statistical Physics 2012 (17 September-21 September). Poster presentation: Garrido, J.A., Luque, N.R., D'Angelo, E, Ros, E. “Homeostatic mechanisms at cerebellar parallel fiber - Purkinje cell connections through deep cerebellar nuclei LTD and LTP”. La Herradura (Spain).

C7/CEREBNET consortium joint meeting (2 October-6 October). Poster presentation: Garrido, J.A., Luque, N.R., D'Angelo, E, Ros, E. “Enhancing learning precision at parallel fiber – Purkinje cell connections through deep cerebellar nuclei LTD and LTP”. Amsterdam (Netherlands).

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Joerg Schreiber

J. Schreiber, M.J. Végh, P. Rao, S. Spijker, C.I. de Zeeuw, A.B. Smit, R.E. van Kesteren. ENP 2012, 10th Dutch Endo-Neuro-Psycho Meeting, 29-31 May 2012. Invited talk: “TRIM3 is a synaptic E3 ubiquitin ligase that affects hippocampal learning”. Lunteren (The Netherlands).

J. Schreiber, M.J. Végh, J. Dawitz, R.M. Meredith, A.B. Smit, R.E. van Kesteren. Society for Neuroscience Meeting 2013. Poster presentation: “TRIM3 is a synaptic E3 ubiquitin ligase that regulates hippocampus-dependent learning”. San Diego (USA).

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Jasper Stroeder

Jasper Stroeder, R.V. Klaassen, J.C. Lodder, J.J.J. Hjorth, F. Coussen, A.B. Smit, H.D. Mansvelder POSTER: Shisa proteins and AMPA-receptor function,  Number:  P115, ONWAR Annual Meeting 2012,  Driebergen-Zeist, November  22 -23

Jasper Stroeder, R.V. Klaassen, J.C. Lodder, J.J.J. Hjorth, F. Coussen, A.B. Smit, H.D. Mansvelder POSTER: Shisa6 is an AMPA-receptor auxiliary protein, Number: P53, Neuroscience Campus Amsterdam Annual Meeting 2013 , Amsterdam, April 7

Jasper Stroeder, R.V. Klaassen, J.C. Lodder, J.J.J. Hjorth, A.B. Smit, H.D. Mansvelder POSTER: Shisa proteins and AMPA-receptor function ; Number: P612.13/D27, Society for Neuroscience Annual Meeting 2013, San Diego, Nov 9-13

Oral Presentation: 

Title: AMPA-receptor regulation by complexation- it is getting complex, ENC-Network satellite Event 2012, Barcelona, July 12

Title: Shisa6 is an AMPA-receptor modulatory protein, abstract pp 129, ONWAR Annual Meeting 2013, Direbergen Zeist, Nov 28-29,

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Marylka Y. Uusisaari.

Talks: 

2013, December: Nucleo-olivary control of olivary network. CEREBNET meeting, London, UK 

2013, August: Cerebellar modulation of electrical coupling in the inferior olive. Gordon research conference, New Hampshire, USA. 

2012, October: Nucleo-olivary neurons of the cerebellum. CEREBNET meeting, Amsterdam, The Netherlands. 

Posters: 

2013, November: Projections from the cerebellar nuclei to the cerebellar cortex: A possible feedback to golgi cells in the cerebello-olivary loop. L. Ankri, Y. Yarom, M.Y. Uusisaari. SfN annual meeting, San Diego, USA.

2013, November: Visualization of the Purkinje neuron to cerebellar nuclei anatomical connectivity using a viral approach. H. Nedelescu,, G. Arbuthnott, B. Kuhn, E. De Schutter, Y. Yarom, M. Y. Uusisaari. SfN annual meeting, San Diego, USA.

2013, November: Cerebellar control of electronic coupling in the inferior olive II: Optogenetic activation of the nucleo-olivary pathway modulates coupling coefficient and sub-threshold oscillations. Y.Lefler, M.Y. Uusisaari, Y.Yarom. SfN annual meeting, San Diego, USA.

2013, November: Cerebellar control of electronic coupling in the inferior olive I: Anatomy of the nucleo-olivary projection. M.Y.Uusisaari, Y. Lefler, Y. Yarom. SfN annual meeting, San Diego, USA.

2013, May: Cerebellar control of electronic coupling in the inferior olive I: Dendritic localization of the GABAergic nucleo-olivary terminals. M.Y. Uusisaari, Y. Lefler, Y. Yarom. C7 meeting, Jerusalem.

2013, May: Cerebellar control of electronic coupling in the inferior olive II: Optogenetic activation of the nucleo-olivary pathway decreases coupling coefficient and eliminates sub-threshold oscillations. Y. Lefler, M.Y. Uusisaari, Y.Yarom. C7 meeting, Jerusalem.

2012, October: In vitro characterization of the cerebellar nucleo-olivary neurons. M. Uusisaari. Poster presentation at SfN 2012, New Orleans, USA.

2012, October: Acute brain slice preparation method from old rodents. S. Huang, M. Uusisaari. Poster presentation at SfN 2012, New Orleans, USA.

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Katarzyna Pietrajtis

Talks:

December 2013. What excites Golgi cells? – oral presentation,Katarzyna Pietrajtis, CEREBNET final meeting, London, United Kingdom.

Everything you always wanted to know about granule cell feedback inhibition* (* but nobody ever told you). Katarzyna Pietrajtis – oral presentation, C7 and CEREBNET meeting, Amsterdam, Netherlands

 

Posters:

November 2013, Optogenetic dissection of granular layer input-output function. Katarzyna Pietrajtis, Oscar Hernandez and Stéphane Dieudonné, Society for Neuroscience 43rd Annual Meeting, San Diego, CA 

March 2013, Granule cell ascending axon excitatory synapses onto Golgi cells implement a potent feedback circuit in the cerebellar granular layer. Katarzyna Pietrajtis, Elisabetta Cesana, Céline Bidoret, Philippe Isope, Egidio D'Angelo, Stéphane Dieudonné and Lia Forti. Third year doctoral school (ED3C) symposium, Roscoff, France 

Synaptic integration in the cerebellar Golgi cell networkKatarzyna Pietrajtis, Stéphane Dieudonné, Second year doctoral school (ED3C) symposium. Paris, France (2012) 

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David Higgins 

Posters:

David Higgins, Nicolas Brunel. CNS, Paris (2013).

David Higgins, Nicolas Brunel. Cosyne, Utah (2013), poster.

The Jansen and Rit Cortical Column Model. David Higgins, Paris Descartes University St. Peres Neuroscience Center retreat, Gif-sur-Yvette, January 2012, poster. 

Talks:

Using OpenCL to Simulate Large Networks, Incorporating Synaptic PlasticityDavid HigginsG-Node Workshop, Munich, (2012) invited speaker 

Memory Maintenance in Calcium-based Plastic Synapses in the Presence of Background Activity. David HigginsComputational Neuroscience Journal Club, September 2013, University of Chicago. Presentation

The Jansen and Rit Cortical Column Model. David Higgins Journal Club, Paris Descartes University (2013). Presentation

 


Publications

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Articles published in 2014

Lefler Y, Uusisaari MY.

Electrical coupling through gap junctions between electrically excitable cells.

Book chapter - Electrochemical Processes in Biological Systems, Wiley (2014)

Articles published in 2013

Huang S, Uusisaari MY.

Physiological temperature during brain slicing enhances the quality of acute slice preparations.  

Front Cell Neurosci 2013. Link here

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Padraig Gleeson, Matteo Cantarelli, Eugenio Piasini, R Angus Silver.

Advanced 3D visualisation of detailed neuronal models using the Open Source Brain repository and interaction with other neuroinformatics resources.

BMC Neuroscience  2013; 14(Suppl 1): P363; Published online 2013 July 8. doi:  10.1186/1471-2202-14-S1-P363 Link here

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H. Nedelescu, G. Arbuthnott, B. Kuhn, E. De Schutter, Y. Yarom, M. Y. Uusisaari.

Visualization of the Purkinje neuron to cerebellar nuclei anatomical connectivity using a viral approach.

Society for Neuroscience Abstracts: 561.14 (2013). Link here

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I. Raikov, T.G. Close, S. Kumar and E. De Schutter.

Challenges of declarative modeling of conductance-based neurons in diverse simulation environments.

BMC Neuroscience 14 (Suppl 1): P94 (2013). Link here

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Owens CB*, Rahmati N*, Bosman LWJ*, Spanke J*, Lindeman S, Gong W, Potters JW, Romano V, Voges K, Moscato L, Koekkoek SKE, Negrello M, DeZeeuw CI. 

Cerebellar potentiation and learning a whisker-based object localization task with a time response window. 

Accepted December 29, 2013: Journal of Neuroscience *Authors contributed equally. (IF:7.271). Link here

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E. D’Angelo, S. Solinas, J. Mapelli, D. Gandolfi, L. Mapelli,  F. Prestori.

The cerebellar Golgi cell and spatiotemporal organization of granular layer activity.

Frontiers in Neural Circuits. May2013 – Volume7 – Article 93. Link here

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Badura A, Schonewille M, Voges K, Galliano E, Renier N, Gao Z, Witter L, Hoebeek FE, Chedotal A, De Zeeuw CI.

Climbing fiber input shapes reciprocity of Purkinje cell firing.

Neuron. 2013 May 22;78(4):700-13. Link here

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Boele HJ, Koekkoek SKE, De Zeeuw CI, Ruigrok TJH.

Axobal Sprouting and Formation of Terminals in the Adult Cerebellum during Associative Motor Learning.

Journal of Neuroscience, November 2013. Link here

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Coesmans M, Roder CH, Smit AE, Koekkoek SK, De Zeeuw CI, Frens MA, van der Geest JN.

Cerebellar motor learning deficits in medicated and medication-free men with recent-onset schizophrenia.

J Psychiatry Neurosci. 2013 Oct 1;38(5):120205. Link here

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Galliano E, Potters JW, Elgersma Y, Wisden W, Kushner SA, De Zeeuw CI, Hoebeek FE.

Synaptic transmission and plasticity at inputs to murine cerebellar purkinje cells are largely dispensable for standard nonmotor tasks.

Journal of Neuroscience. 2013;33(31):12599-618. Link here

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Gutierrez-Castellanos N, Winkelman BH, Tolosa-Rodriguez L, De Gruijl JR, De Zeeuw CI.

Impact of aging on long-term ocular reflex adaptation.

Neurobiol Aging. 2013 Dec;34(12):2784-92. Link here

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Gutierrez-Castellanos N, Winkelman BH, Tolosa-Rodriguez L, Devenney B, Reeves RH, De Zeeuw CI.

Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatment.

J Neurosci. 2013 Sep 25;33(39):15408-13. Link here

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Onuki Y, Van Someren EJ, De Zeeuw CI, Van der Werf YD.

Hippocampal-Cerebellar Interaction During Spatio-Temporal Prediction.

Cereb Cortex. 2013 Aug 22. Link here

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Rahmati N, Kunzelmann K, Xu J, Barone S, Sirianant L, De Zeeuw CI, Soleimani M.

Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H(+)-ATPase.

Pflugers Arch. 2013 Nov;465(11):1583-97. Link here

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Spitzmaul G, Tolosa L, Winkelman BHJ, Heidenreich M, Frens MA, Chabbert C, De Zeeuw CI, Jentsch TJ.

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.

Journal of Biological Chemistry. 2013;288(13):9334-44. Link here

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van Beugen BJ, Gao Z, Boele HJ, Hoebeek F, De Zeeuw CI.

High frequency burst firing of granule cells ensures transmission at the parallel fiber to purkinje cell synapse at the cost of temporal coding.

Front Neural Circuits. 2013;7:95. Link here

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Witter L, Canto CB, Hoogland TM, de Gruijl JR, De Zeeuw CI.

Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation.

Front Neural Circuits. 2013;7:133. Link here

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Yaara Lefler, Benjamin Torben-Nielsen, and Yosef Yarom

Oscillatory activity, phase differences, and phase resetting in the inferior olivary nucleus.

Front Syst Neurosci. 2013; 7: 22. Published online 2013 June 19. Prepublished online 2013 April 19.doi:  10.3389/fnsys.2013.00022 PMCID: PMC3685800. Link here

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Anwar H, Hepburn I, Nedelescu H, Chen W, De Schutter E. 

Stochastic calcium mechanisms cause dendritic calcium spike variability.

J Neurosci. 2013 Oct 2;33(40):15848-67. doi: 10.1523/JNEUROSCI.1722-13.2013. Link here.

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Hermina Nedelescu and Mohamed Abdelhack.

Comparative Morphology of Dendritic Arbors in Populations of Purkinje Cells in Mouse Sulcus and Apex.

Neural Plasticity, Volume 2013 (2013), Article ID 948587, 12 pages. Link here.

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F. Prestori, C. Bonardi, L. Mapelli, P. Lombardo, R. Goselink, M. Egle De Stefano, D. Gandolfi, J. Mapelli, D. Bertrand, M. Schonewille, C. De Zeeuw, E. D’Angelo.

Gating of Long-Term Potentiation by Nicotinic Acetylcholine Receptors at the Cerebellum Input Stage. 

Plos One. May 2013 – Volume 8 – Issue 5 – e64828. Link Here

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Garrido, J. A.; Luque, N. R.; D'Angelo, E.; Ros, E. (2013): “Distributed cerebellar plasticity implements adaptable gain control in a manipulation task: a closed-loop robotic simulation”. Frontiers in Neural Circuits 7, 159. Link here

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D'Angelo, E.; Solinas, S.; Garrido, J. A.; Casellato, C.; Pedrocchi, A.; Mapelli, J.; Galdolfi, D.; Prestori, F. (2013): “Realistic modeling of neurons and networks: towards brain simulation”. Functional Neurology. The Human Brain Project, 153 – 166. Link here

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J. A Garrido, E. Ros, E. D‘Angelo. 

Spike timing regulation on the millisecond scale by distributed synaptic plasticity at the cerebellum input stage: a simulation study.

Frontiers in computational neuroscience. May 2013 – Volume7 – Article 64. Link here

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E. Galliano, Z. Gao, M. Schonewille, B. Todorov, E. Simons, A.S. Pop, E. D’Angelo, A.M.J.M. van den Maagdenberg, F.E. Hoebeek, and C.I. De Zeeuw. 

Silencing the Majority of Cerebellar Granule Cells Uncovers Their Essential Role in Motor Learning and Consolidation.

Cell Reports, 11 April 2013. Link here 

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E. Galliano, M. Baratella, M. Sgritta, T.J.H.Ruigrok, E.D.Haasdijk, F.E.Hoebeek, E. D’Angelo, D. Jaarsma and C. DeZeeuw. 

Anatomical investigation of potential contacts between climbing fibers and cerebellar Golgi cells in the mouse. 

Frontiers in Neural Circuits. Vol. 7, article 59. April 2013. Link here

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D. Gandolfi, P. Lombardo, J. Mapelli, S. Solinas and E. D’Angelo.

Theta-frequency resonance at the cerebellum input stage improves spike timing on the millisecond time-scale.

Frontiers in Neural Circuits. Vol. 7, article 64. April 2013. Link here

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Locatelli F, Botta L, Prestori F, Masetto S, D’Angelo E.

Late-onset bursts evoked by mossy fibre bundle stimulation in unipolar brush cells: evidence for the involvement of H- and TRP-currents.

J Physiol. 15;591(Pt 4):899-918. 2013 Feb Link here

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E. D’Angelo, S. Casali.

Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition.

Frontiers in Neural Circuits. Vol 6, article 116, January 2013. Link here

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E. Cesana, K. Pietrajtis, C.line Bidoret, P. Isope, E. D’Angelo, S. Dieudonne, and L. Forti.

Granule cell ascending axon excitatory synapses onto Golgi cells implement a potent feedback circuit in the cerebellar granular layer.

Paper #JN-RM-4897-11R2. Journal of Neuroscience. 2013 Link here

Articles published in 2012

H. Nedelescu, M. Negrello, H. Cuntz, M. Häusser, A. Watt and E. De Schutter.

Tracking anatomical changes in the maturing Purkinje cell dendritic forest.

Society for Neuroscience Abstracts: 734.05 (2012). Link here

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Katarzyna Pietrajtis and Stéphane Dieudonné.

Golgi neurons.       

in “Handbook of Cerebellum and Cerebellar Disorders”, SpringerLink; Manto, M.; Gruol, D.; Schmahmann, J.; Koibuchi, N.; Rossi, F. (Eds.) ISBN 978-94-007-1333-8 . Link here        

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Baudouin SJ, Gaudias J, Gerharz S, Hatstatt L, Zhou K, Punnakkal P, Tanaka KF, Spooren W, Hen R, De Zeeuw CI, Vogt K, Scheiffele P.

Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism.

Science. 2012;338(6103):128-32. Link here

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de Gruijl JR, Bazzigaluppi P, de Jeu MTG, de Zeeuw CI.

Climbing Fiber Burst Size and Olivary Sub-threshold Oscillations in a Network Setting.

PLoS Computational Biology. 2012;8(12). Link here

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Gao Z, Van Beugen BJ, De Zeeuw CI.

Distributed synergistic plasticity and cerebellar learning.

Nature Reviews Neuroscience. 2012;13(9):619-35. Link here

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Saab AS, Neumeyer A, Jahn HM, Cupido A, Šimek AAM, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI, Kirchhoff F.

Bergmann glial AMPA receptors are required for fine motor coordination.

Science. 2012;337(6095):749-53. Link here

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Seja P, Schonewille M, Spitzmaul G, Badura A, Klein I, Rudhard Y, Wisden W, Hübner CA, De Zeeuw CI, Jentsch TJ.

Raising cytosolic Cl - in cerebellar granule cells affects their excitability and vestibulo-ocular learning.

EMBO Journal. 2012;31(5):1217-30. Link here

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van Versendaal D, Rajendran R, Saiepour M, Klooster J, Smit-Rigter L, Sommeijer JP, De Zeeuw C, Hofer S, Heimel J, Levelt C.

Elimination of Inhibitory Synapses Is a Major Component of Adult Ocular Dominance Plasticity. 

Neuron. 2012;74(2):374-83. Link here

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Vinueza Veloz MF, Buijsen RAM, Willemsen R, Cupido A, Bosman LWJ, Koekkoek SKE, Potters JW, Oostra BA, De Zeeuw CI.

The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice.

Genes, Brain and Behavior. 2012;11(3):325-31. Link here

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Voogd J, Schraa-Tam CKL, Van Der Geest JN, De Zeeuw CI.

Visuomotor cerebellum in human and nonhuman primates.

Cerebellum. 2012;11(2):392-410. Link here

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Jornt R. De Gruijl, Paolo Bazzigaluppi, Marcel T. G. de Jeu, Chris I. De Zeeuw

Climbing Fiber Burst Size and Olivary Sub-threshold Oscillations in a Network Setting

Research Article | published 13 Dec 2012 | PLOS Computational Biology. 10.1371/journal.pcbi.1002814 Link here

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Benjamin Torben-Nielsen, Idan Segev, Yosef Yarom

The Generation of Phase Differences and Frequency Changes in a Network Model of Inferior Olive Subthreshold Oscillations

Research Article, published 05 Jul 2012, PLOS Computational Biology. 10.1371/journal.pcbi.1002580 Link here

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Padraig Gleeson, Eugenio Piasini, Sharon Crook, Robert Cannon, Volker Steuber, Dieter Jaeger, Sergio Solinas, Egidio D'Angelo, Angus Silver. 

The Open Source Brain Initiative: enabling collaborative modelling in computational neuroscience.

BMC Neuroscience, July 2012, 13:O7, Link here

Articles published in 2011

Bosman LWJ, Houweling AR, Owens CB, Tanke N, Shevchouk OT, Rahmati N, Teunissen WHT, Ju C, Gong W, Koekkoek SKE, de Zeeuw CI.

Anatomical pathways involved in generating and sensing rhythmic whisker movements.

Frontiers in Integrative Neuroscience. 2011;5. Link here

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De Zeeuw CI, Hoebeek FE, Bosman LWJ, Schonewille M, Witter L, Koekkoek SK.

Spatiotemporal firing patterns in the cerebellum.

Nature Reviews Neuroscience. 2011;12(6):327-44. Link here

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Luthman J, Hoebeek FE, Maex R, Davey N, Adams R, De Zeeuw CI, Steuber V.

STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron.

Cerebellum. 2011;10(4):667-82. Link here

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Schonewille M, Gao Z, Boele HJ, Vinueza Veloz M, Amerika W, Šimek A, De Jeu M, Steinberg J, Takamiya K, Hoebeek F, Linden D, Huganir R, De Zeeuw C.

Reevaluating the Role of LTD in Cerebellar Motor Learning.

Neuron. 2011;70(1):43-50. Link here

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van der Vaart T, van Woerden GM, Elgersma Y, de Zeeuw CI, Schonewille M.

Motor deficits in neurofibromatosis type 1 mice: The role of the cerebellum.

Genes, Brain and Behavior. 2011;10(4):404-9. Link here

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Bosman LWJ, Houweling AR, Owens CB, Tanke N, Shevchouk OT, Rahmati N, Teunissen WHT, Ju C, Gong W, Koekkoek SKE, De Zeeuw CI

Anatomical pathways involved in generating and sensing rhythmic whisker movements. 

Frontiers in Integrative Neuroscience. Volume 5 Article 53 pp 1-28. 2011 Link here. 

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D'Angelo E.

Neural circuits of the cerebellum: hypothesis for function. 

J Integr Neurosci. 2011 Sep;10(3):317-52. Link here.

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Diwakar S, Lombardo P, Solinas S, Naldi G, D'Angelo E.

Local field potential modeling predicts dense activation in cerebellar granule cells clusters under LTP and LTD control.

PLoS One. 2011;6(7).  Link here. 

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Symposium Reviews - Egidio D'Angelo, Rodolfo R. Llinás, Christian Hansel, Marylka Uusisaari and Paul Dean. 

The cerebellum: from neurons to higher control and cognition - The cerebbllum: from neurons to higher control and cognition

The journal of Physiology. 15 July 2011 - Volume 589 Number 14. Link here

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D’Angelo E. (2011).

The cerebellar network: revisiting the critical issues.

J Physiol. 2011 Jul 15;589(Pt 14):3421-2. Epub 2011 Jun 13 Link here

Articles published in 2010

Burguière E, Arabo A, Jarlier F, De Zeeuw CI, Rondi-Reig L.

Role of the cerebellar cortex in conditioned goal-directed behavior.

Journal of Neuroscience. 2010;30(40):13265-71. Link here

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Schonewille M, Belmeguenai A, Koekkoek SK, Houtman SH, Boele HJ, van Beugen BJ, Gao Z, Badura A, Ohtsuki G, Amerika WE, Hosy E, Hoebeek FE, Elgersma Y, Hansel C, De Zeeuw CI.

Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning.

Neuron. 2010;67(4):618-28. Link here

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Bosman LWJ, Koekkoek KE, Shapiro J, Rijken BFM, Zandstra F, van der Ende B, Owens CB, Potters JW, de Gruijl JR, Ruigrok TJH, DeZeeuw CI. 2010.

Encoding of whisker input by cerebellar Purkinje cells. 

Journal of Physiology 588.19, pp 3757-3783. 2010 Link here.

Rebuilding cerebellar network computations from cellular neurophysiology (2010)

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Cerebnet

B_foto_cerebnet

This schematic drawing shows the most relevant connections within a cerebellar module. The mossy fibers contact granule cells (GrC) and deep cerebellar nuclei (DCN) cells which, in turn, receive inhibition from the same common set of Purkinje cells (PC). Moreover, the interior olive (IO) cells emit climbing fibers that contact DCN cells and Purkinje cells (PC), which also project to the same DCN cells. An activate group of GrCs is in (red), while others (yellow) are laterally inhibited by the GoCs. The active GrCs excite the overlaying PCs (dark red) according to a vertical organization pattern (Bower and Woolston, 1983). The PCs inhibit DCN neurons which in turn inhibit the IO neurons. Note that, within a cerebellar module, different circuit elements communicate in closed loops. The mossy fibers contact granule cells and DCN cells which, in turn, receive inhibition from the same common set of Purkinje cells. Moreover, the IO cells emit climbing fibers that contact DCN and PC, which also project to the same DCN cells.

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